The founders, Henry Arthur Callis, Charles Henry Chapman, Eugene Kinckle Jones, George Biddle Kelley, Nathaniel Allison Murray, Robert Harold Ogle, and Vertner Woodson Tandy, are collectively known as the "Seven Jewels". The fraternity expanded when second and third chapters were chartered at Howard University and Virginia Union University in 1907. Beginning in 1908, Alpha Phi Alpha became the prototype for other Black Greek Letter Organizations (BGLO). Today, there are over 680 active Alpha chapters in the Americas, Africa, Europe, Asia, the West Indies, and the Virgin Islands.

Alpha Phi Alpha evolved into a primarily service organization and has provided leadership and service during the Great Depression, World Wars, Civil Rights Movements, and addresses social issues such as apartheid, AIDS, urban housing, and other economic, cultural, and political issues affecting people of color. The Martin Luther King, Jr. National Memorial and World Policy Council are programs of Alpha Phi Alpha, and the fraternity jointly leads philanthropic programming initiatives with March of Dimes, Head Start, Boy Scouts of America and Big Brothers Big Sisters of America.

Members of Alpha Phi Alpha include Jamaican Premier and Rhodes Scholar Norman Manley, Nobel Prize winner Martin Luther King, Jr., U.S. Vice President Hubert Humphrey, Olympian Jesse Owens, Justice Thurgood Marshall, United Nations Ambassador Andrew Young, and Atlanta Mayor Maynard Jackson. Numerous other American leaders are among the men who have adopted the fraternity’s principles—manly deeds, scholarship, and love for all mankind.